Date of Award

5-1-2014

Document Type

Article

Degree Name

Bachelor of Science

First Advisor

Damien Thevenin

Abstract

The pH Low Insertion Peptide (pHLIP) is able to unidirectionally insert itself in membranes at low pH, a physiological marker of cancerous cells. Thus, the pHLIP peptide has potential use as a dual targeting and delivery system for cancer therapeutics. We are investigating pHLIP-protein constructs to further our understanding of protein-membrane interactions and pHLIP dynamics in an attempt to target proteins to cancer cell membranes.

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