Date

2019

Document Type

Thesis

Degree

Master of Science

Department

Mechanical Engineering

First Adviser

Liu, Yaling

Abstract

This thesis consists of three sections. First, some background information and theories about the erythrocyte membrane are provided. Second, a coarse-grained molecular dynamics model for a patch of erythrocyte membrane is built up. Third, the mechanical responses of the patch of red blood cells to diffusion and diffusivity, tension, rupture, and shear-induced pore area are analyzed.The patch of erythrocyte membrane is validated by modeling diffusivity and determining the diffusion coefficient constant. Then, the patch of the coarse-grained erythrocyte membrane is stretched uniformly until rupture. The critical stress/strain from simulation match with those obtained in experiments in laser optical tweezers trapping a bead. Lastly, the pore area of the patch of erythrocyte membrane at the high-stress region is determined over a range of deformations.The purpose of creating the patch of erythrocyte membrane is to reduce computational cost, obtain accurate and detailed answers from our interested regime conditions, and transfer some quantities from nanoscale to mesoscale by solving time and length scale gaps.

Share

COinS