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Living cells as physical entities can response the changes of the physiological environment as well as mechanical stimuli occurring in and out of the cell body. It is well documented that cell directional motion is determined by the substrate stiffness. Cells tend to move towards stiffer substrate. Cytoskeleton plays a significant role in intracellular force equilibrium and extracellular force balance between substrate and cell via focal adhesions. Cellular deformations can be evaluated by the use of computational models.